What are exosomes?

Exosomes are small extracellular vesicles that act as cellular messengers. They carry biological instructions related to regeneration, repair, and rejuvenation processes. They constitute a natural and highly efficient communication mechanism present in all living organisms.

Each exosome can carry micronutrients, proteins, lipids, enzymes, and antioxidants, among other bioactive components. Thanks to their lipid bilayer structure, they easily integrate with human cells, facilitating the transfer of their contents.

They are biomimetic structures, naturally occurring and with a high safety profile.

Plant-derived exosomes offer significant advantages over animal- or synthetic-derived exosomes, both in terms of safety and efficacy, as well as providing a greater wealth of natural bioactive compounds.

What is EXOREVAGE?

EXOREVAGE is a patent-pending technology developed by PREBEL.
EXOREVAGE is a registered trademark owned by PREBEL.

It is a complex of functionalized plant exosomes that integrates:

Exosomes derived from plant stem cells obtained through green biotechnology.
A lipid permeation enhancer.
Ionic cofactors.

In EXOREVAGEPlant-derived exosomes are modified by incorporating a lipid permeation enhancer and ionic cofactors derived from precious stones. This combination results in a smart delivery system with biomimetic membranes, high safety, high efficacy, and controlled release of bioactive compounds.

The integration of the permeation enhancer optimizes cell fusion in the skin and promotes more efficient release of the exosomal content. In turn, ionic cofactors modulate the surface charge of exosomes and allow the formation of coordination complexes with receptors and cell membranes, improving interaction with skin cells, providing selective affinity, and amplifying efficacy.

This technology developed by PREBEL enables the creation of advanced, customized solutions for skin and hair care applications.

How is EXOREVAGE® formed?

Conventional plant exosomes → EXOREVAGE: functionalized plant exosomes

Unlike conventional plant exosomes, EXOREVAGE is based on functionalized plant exosomes. This means that the exosomes are structurally modified by:

A lipid permeation booster that integrates into your membranes and optimizes cell fusion in the skin.
Ionic cofactors derived from gemstones, which modulate the surface charge of exosomes and enable the formation of coordination complexes with receptors and cell membranes.

This structural modification provides more efficient release of the exosomal content and greater selective affinity, optimizing the interaction between exosomes and target cells.

Main advantages of EXOREVAGE functionalized plant exosomes

Greater structural stability.
More uniform structure.
Optimized cell fusion with the target skin cell.
Greater bioavailability of bioactive compounds.
Improved cellular communication between exosomes and target cells.

Structure of functionalized exosomes in EXOREVAGE

Functionalized exosomes from EXOREVAGE are developed from three main components, each with specific functions:

Plant-derived exosomes: They transport biological information, specialized bioactives, and plant-derived peptides. They perform key functions in cell signaling.
Ionic cofactors: They modify the surface charge and form coordination complexes with receptors and cell membranes. This improves the interaction between exosomes and skin cells, providing selective affinity and enhancing efficacy.
Permeation enhancer: It integrates into exosomal membranes, optimizes cell fusion, and promotes more efficient release of bioactive content.

These components are not combined superficially. They are structurally integrated to modify the architecture of the exosome and give rise to functionalized plant exosomes, constituting cutting-edge technology for advanced applications in skin and hair care.