ANTI-AGING REGENERATING CREAM FACE & NECK is perfect to prevent the appearance of signs of skin aging. Revitalizes and reduces wrinkles and fine lines on the face, providing greater elasticity and firmness to the skin in the face and neck. Powered by EXOREVAGE® CICA, a patent-pending functionalized plant-exosome technology derived from Centella asiatica. Rooted in ancestral botanical tradition and evolved through green biotechnology, plant-exosomes are sustainably obtained from stem-cell platforms and functionalized to enhance bioactivity and targeted performance. Integrated by the precious heritage of pearl and boosted with biomimetic vegetable based squalane, EXOREVAGE® CICA delivers a non-invasive and needle-free approach.

Unlike conventional plant-based exosomes, EXOREVAGE® CICA is a technology of functionalized plant-based exosomes from Centella asiatica modified with squalane as a lipidic permeation booster that integrates in its membranes and optimizes cell fusion in the skin and ionic cofactors of calcium coming from precious pearl gemstone which modulate the surface charge of the exosomes, enabling the formation of coordination complexes with cellular receptors and membranes.This modification provides a more effective release of exosome content and selective affinity to enhance the interaction between exosomes and skin cells.  This smart biomimetic delivery system supports cellular regeneration and improves skin texture.

TEXTURE: Rich and nourishing cream not greasy with smoot consistency and fast absorption delivering lasting hydration, protection and nutrition, like applying a second skin.

PREBEL EXOREVAGE® CICA technology – enabled claim:

• Up to 2 billlion of functionalized plant exosomes from CICA/mL of product (1)
• The plant-based exosomes in EXOREVAGE® CICA are functionalized, meaning that are more stable and more uniform structure compared to conventional CICA exosomes (2)
• Up to 20% higher antioxidant capacity compared to common CICA exosomes (3)
• Up to 72% of skin recovery process compared to the baseline control and has a Similar effect to skin growth factors (4)
• The firmness increased significantly by up to 19% at 56 days and the Elasticity increased significantly by up to 8% (5)
• Total rejuvenating effect with overall improvement in 6 parameters: Up to 78%, in Wrinkle reduction, Up to 51% in Roughness reduction, Up to 65% of Pore reduction, Up to 30% of Patch reduction, Up to 63% of Red spot reduction using Cross polarized light and Up to 57% Porphyrin reduction using UV Light (5)
• More effective release of bioactives: Due to the integration of the squalane as a lipidic permeation booster in the Centella asiatica exosome membranes
• More selective affinity with target skin cells: Due to the modulated surface charge of Centella asiatica exosomes mediated by the calcium ions from precious pearl gemstone.

1. Supported by tests of determination of particle concentration and size by Nanosight
2. Supported by test of  Nanosight and Scanning Electron Microscopy (SEM)
3. Supporte by test of antixidant capacity with DPPH (2,2-Diphenyl-1-picrylhydrazyl)
4. In vitro tests in Human Dermal Fibroblasts (HDF),In vivo clinical tests performed with 20 subjects

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