FUNCTIONALIZEDEXOSOMES
FROM CENTELLA ASIATICA
The Trend
The growing scientific focus on skin longevity has shifted skincare from short-term cosmetic correction toward strategies that preserve cellular function, barrier integrity, and tissue resilience over time. Conventional soothing and repair actives often show limited capacity to modulate the biological processes associated with oxidative stress, and impaired intercellular communication which are key drivers of premature skin aging.
Advances in plant-derived exosomes are designed to enhance intercellular signaling and targeted bioactive delivery. By supporting regenerative pathways,reinforcing barrier function, and promoting adaptive stress response, this technology contributes to the preservation of healthy, resilient skin and long-term skin
longevity.
Consumer data from Mintel shows:
- Recent patents highlight the use of exosomes, micelles and nanoparticles to enhance skincare ingredient absorption for better results. (Source: Patent Insights: Boost Skincare Ingredient Absorption. Mintel, 2025)
- Advances in longevity research have led to innovations in biohacking and cellular rejuvenation, targeting the root causes of ageing. A notable breakthrough includes the use of exosomes for hair and skin rejuvenation (Source: China Haircare Market Report 2025. Mintel, 2025)
- Explore plant-based sources for exosomal therapy solutions to avoid the eco-ethical considerations that can arise from using a product derived from human stem cells (Source: Patent insights: trending VMS ingredients in BPC. Mintel, 2025)
- 27% of US facial skincare product buyers are interested in trying products powered by longevity research (Source: Patent insights: frontiers in skin longevity. Mintel, 2025)
- Centella asiatica is widely used in skincare for its soothing, calming, and restorative properties inspired by its wide use in Korean skin care. It is a popular ingredient in both Asian and global markets, often featured in products targeting sensitive, irritated, or post-procedure skin. Recently, it’s been used in Suncare to help sooth skin while also protecting sensitive skin against UVA/UVB rays and pollution (Source: A year of innovation in suncare, 2025. Mintel, 2025)
What is EXOREVAGE® CICA?
THE PLANT BIOTECNOLOGY REVOLUTION TO REVERSE SKIN CELLULAR AGE.
EXOREVAGE® CICA is a patent-pending technology developed by PREBEL. This technology was specially created to formulate needle-free and non- invasive skin care products
In EXOREVAGE® CICA the plant exosomes from Centella asiatica are modified with squalane (lipidic permeation booster) and ionic cofactors of calcium coming from precious pearl gemstone to create a smart delivery system with biomimetic membranes, high safety and efficacy and controlled release of bioactive compounds, enhancing cell regeneration, reversing skin senescence and improving skin texture.
The plant based exosomes from Centella asiatica and squalane are both obtained green biotechnology.
This technology is versatile enough to be formulated with other active ingredients and fragrances. It can be used to formulate transparent and non-transparent products, solutions, emulsions, cleansers and the other cosmetic forms.
Hero Ingredients in EXOREVAGE® CICA?
We have selected strategically both the most effective and functional ingredients to create modified plant-based exosomes. These components are not simply mixed together, this technology goes beyond. In EXOREVAGE® CICA, these components are integrated to modify the exosome structure and enable to form functionalized exosomes from Centella Asiatica, as a cutting edge technology for skin care applications.
Squalane
Squalane is high purity ingrediente that mimics the skin´s natural oils, making it an excellent emollient.
It´s obtained from sugarcane using fermentation by green biotechnology.
Precious Pearl Gemstone
Precious Pearl is a liquid extract from the marine gemstone rich in calcium from aragonite. It can nourish the skin and slow down aging processes by improving the metabolism, supporting moisturisation, and protection against environmental-damage effects.
Plant-Based Exosomes From Centella Asiatica
Exosomes from Centella Asiatica stem cells which transport signaling peptides, such as growth factor and epigenetic factors, which can communicate with human follicles, and reactive the hair cycle and hair growth.
Structure of Functionalized Exosomes
in EXOREVAGE® CICA
The functionalized exosomes in EXOREVAGE® CICA are created by using three main components with very specialized roles:
PLANT-BASED EXOSOMES FROM CICA: Carry information, specialized bioactives and plant-based peptides and it has cell signaling functions
CALCIUM IONS (IONIC COFACTORS): Coming from precious pearl. Change the surface charge and form coordination complexes with receptors and membranes. Enhance the interaction between exosomes and skin cells, providing selective affinity and amplifying the efficacy
SQUALANE (PERMEATION BOOSTER): Integrates in the exosomes membranes and optimizes cell fusion and promotes more effective release of exosome content.
Comparison between Conventional
Exosomes from Cica
and EXOREVAGE® CICA
Particle Size Distribution
Scanning Electron Microscopy (SEM)
The structure of the plant-based exosomes was analized by means of scanning electron microscopy (SEM).
Conventional plant-based exosomes from Centella asiatica show irregular and heterogeneous morphology, with poorly defined edges, greater size variability. In contrast, the functionalized plant-based exosomes in EXOREVAGE® CICA exhibited a well-defined spherical morphology, with sharp contours, greater uniformity in size, and a more compact surface texture, characteristics that evidence the formation of a stable coating and effective functionalization.
These results indicate more stable and more uniform structure of EXOREVAGE® CICA compared to conventional Centella Asiatica exosomes.
In Vitro Tests
Regenerative properties
The regenerative properties of EXOREVAGE® CICA was evaluated by scratch test in Human Dermal Fibroblasts (HDF), showing that EXOREVAGE CICA accelerates the skin recovery process by up to 72% compared to the baseline control and has a Similar effect to skin growth factors
Antioxidant Capacity
EXOREVAGE® CICA was evaluated against conventional plant- based exosomes from Centella asiatica (CICA) in antioxidant capacity test using DPPH quantifying the mg Equivalent Trolox/ 100mL. It’s found up to 20% higher antioxidant capacity in EXOREVAGE® CICA compared to conventional CICA exosomes.
In Vivo Tests
In vivo tests conducted with 20 volunteers using a leave-on formula with EXOREVAGE® CICA for 56 days
- Firmness and Elasticity: The firmness increased significantly by up to 19% at 56 days and the Elasticity increased significantly by up to 8% when using a cream with EXOREVAGE® CICA
- Total rejuvenating effect: The skin of the volunteers was analyzed by using high-resolution facial imaging with VISIA ® at multi-spectral lighting (white, cross-polarized, and UV) and 3D positioning to consistently capture surface and subsurface skin features, enabling accurate before-and-after comparisons. The results showed a total rejuvenating effect with overall improvement in 6 parameters: Up to 78%, in Wrinkle reduction, Up to 51% in Roughness reduction, Up to 65% of Pore reduction, Up to 30% of Patch reduction, Up to 63% of Red spot reduction using Cross polarized light and Up to 57% Porphyrin reduction using UV Light.
Our product
