FUNCTIONALIZEDEXOSOMES
FROM CENTELLA ASIATICA
The Trend
The growing scientific focus on skin longevity has transformed skincare: moving from immediate-correction cosmetic solutions toward strategies oriented at preserving cellular function, barrier integrity, and tissue resilience over time.
Traditional soothing and repairing actives often show a limited capacity to modulate key biological processes associated with premature aging, such as oxidative stress and impaired intercellular communication.
In this context, advances in plant-derived exosomes represent a new technological generation designed to optimize cellular signaling and targeted bioactive delivery. By supporting regenerative pathways, reinforcing barrier function, and promoting an adaptive response to stress, this technology contributes to preserving healthy, resilient skin with greater longevity.
Trend Insights – Mintel (2025):
- Patents: Recent patents highlight the use of exosomes, micelles, and nanoparticles to improve ingredient absorption in skincare and enhance results.
- Biohacking: Advances in longevity research have driven innovations in biohacking and cellular rejuvenation, including the use of exosomes for skin and hair regeneration.
- Ethical Sourcing: Exploration of plant sources for exosomal therapies is being promoted to avoid the ethical and environmental considerations associated with human stem cell-derived exosomes.
- Consumer Interest: 27% of facial product buyers in the US express interest in trying products backed by longevity research.
- Centella asiatica is widely recognized for its soothing, repairing, and restorative properties. It is a key ingredient in Asian and global markets, especially in products for sensitive, irritated, or post-procedure skin. Recently, its use has extended into suncare, where it helps soothe the skin and reinforce protection against UVA/UVB radiation and pollution.
What is EXOREVAGE CICA?
The revolution in plant biotechnology to reverse cellular skin age.
EXOREVAGE CICA is a patent-pending technology developed by PREBEL, created specifically for the formulation of non-invasive, needle-free dermocosmetic products.
The technology integrates plant exosomes derived from Centella asiatica, modified with squalane—a lipid permeation enhancer—and ionic calcium cofactors derived from precious pearls. The result is an intelligent delivery system featuring biomimetic membranes, high safety and efficacy, and controlled release of bioactive compounds.
This system promotes cellular regeneration, helps reverse skin senescence processes, and visibly improves skin texture.
Both the Centella asiatica exosomes and the squalane are obtained through green biotechnology processes. Centella asiatica como el escualano se obtienen mediante procesos de biotecnología verde.
The technology is versatile and can be formulated in combination with other actives and fragrances, in transparent and non-transparent products, solutions, emulsions, cleansers, and various cosmetic forms.
Key Ingredients of EXOREVAGE CICA?
The selection of ingredients responds to strategic criteria of efficacy and functionality. This is not a simple combination of components: in EXOREVAGE CICA, these are structurally integrated to modify the architecture of the exosome and generate functionalized Centella asiatica exosomes, representing cutting-edge technology for skincare applications. Centella asiatica, representando una tecnología de vanguardia para aplicaciones en cuidado de la piel.
Squalane
A high-purity ingredient that biomimics the skin’s natural lipids, acting as a highly effective emollient.
Sourced from sugar cane through green biotechnology fermentation.
Precious Pearl
A liquid extract derived from marine pearls, rich in aragonite-sourced calcium. It helps nourish the skin, optimize metabolism, promote hydration, and protect against environmental aggressors, helping to decelerate aging-related processes.
Plant-derived Centella asiatica Exosomes
Act as biological signaling vehicles, transporting peptides and bioactive factors—including growth factors and epigenetic modulators—capable of interacting with human cells and stimulating regenerative processes.
Functionalized exosome structure
in EXOREVAGE® CICA
The functionalized exosomes are developed from three main components with specific technical functions:
CICA Plant Exosomes: Carry biological information, specialized bioactives, and plant peptides, performing cellular signaling functions.
Calcium Ions (Ionic Cofactors): Derived from precious pearls. They modify surface charge and form coordination complexes with receptors and cell membranes, favoring interaction with skin cells, providing selective affinity, and amplifying efficacy.
Squalane (Permeation Enhancer): Integrates into the exosomal membrane, optimizing cellular fusion and promoting a more efficient release of bioactive content.
Comparison between conventional
CICA y and EXOREVAGE CICA
Particle size distribution
Conventional Centella asiatica Presents an average size of approximately 238 nm with a polydisperse distribution.
Following functionalization in EXOREVAGE , the average size increases to approximately 311 nm (a 23% increase), accompanied by a more homogeneous distribution.
These changes demonstrate structural reorganization and increased stability derived from interaction with functional components.
The particle concentration increases from 4.71 × 10¹⁰ particles/mL in conventional exosomes to 1.01 × 10¹¹ particles/mL in EXOREVAGE CICA, indicating better dispersion and greater physical stability.
Overall, the results demonstrate a more uniform and stable structure in EXOREVAGE CICA.
Scanning Electron Microscopy (SEM)
SEM analysis showed that conventional Centella asiatica xosomes have irregular and heterogeneous morphology, with poorly defined edges and greater variability in size.
In contrast, the functionalized exosomes in EXOREVAGE CICA exhibit well-defined spherical morphology, sharp contours, greater uniformity, and a more compact surface, demonstrating effective functionalization and the formation of a stable coating.
In Vitro Trials
Regenerative properties
Evaluated using a scratch test on human dermal fibroblasts (HDF), where EXOREVAGE CICA accelerated the skin recovery process by up to 72% compared to the baseline control, showing an effect comparable to that of dermal growth factors.
Antioxidant Capacity
In a DPPH assay (mg Trolox equivalents/100 mL), EXOREVAGE CICA showed up to 20% higher antioxidant capacity compared to conventional CICA exosomes.
In Vivo Trials
Study conducted on 20 volunteers over 56 days using a leave-on formula with EXOREVAGE CICA.
Firmness and elasticity:
- Significant increase in firmness of up to 19% after 56 days.
- Significant increase in elasticity of up to 8% with the use of cream containing EXOREVAGE CICA. CICA.
Firmeza y elasticidad
- Significant increase in firmness of up to 19% after 56 days.
- Significant increase in elasticity of up to 8% with the use of cream containing EXOREVAGE CICA. CICA.
Firmness and elasticity
The skin was evaluated using the VISIA high-resolution facial imaging system with multispectral lighting and 3D positioning, allowing for accurate comparisons before and after treatment.
An overall rejuvenating effect was observed with improvement in six parameters:
- Up to 78% reduction in wrinkles
- Up to 51% reduction in roughness
- Up to 65% reduction in pores
- Up to 30% reduction in spots
- Up to 63% reduction in red spots (cross-polarized light)
- Up to 57% reduction in porphyrins (UV light)
Our Product
