{"id":9867,"date":"2025-12-18T17:52:30","date_gmt":"2025-12-18T22:52:30","guid":{"rendered":"https:\/\/prebel.com\/?page_id=9867"},"modified":"2026-03-03T09:01:42","modified_gmt":"2026-03-03T14:01:42","slug":"exorevage-curcuma","status":"publish","type":"page","link":"https:\/\/prebel.com\/en\/exorevage-curcuma\/","title":{"rendered":"exorevage-curcuma"},"content":{"rendered":"
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t
<\/div>
<\/div>


FUNCTIONALIZED<\/br> EXOSOMES
\nFROM CURCUMA LONGA <\/strong>\n<\/div>
Patent-pending technology <\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t
\n\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t

The Trend<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

The growing scientific focus on scalp and hair longevity is transforming hair care: it is no longer just about cosmetic conditioning, but about preserving follicular function, scalp balance, and hair fiber quality over time.<\/p>

Traditional soothing and strengthening actives often have limited reach against the biological mechanisms associated with follicular aging, oxidative stress, and disrupted cellular communication. Added to this is chronic exposure to environmental factors such as UV radiation, pollution, and mechanical damage, which accelerate scalp deterioration and the loss of hair vitality.<\/p>

In this context, advances in plant-derived exosomes represent a new technological generation aimed at optimizing intercellular signaling and the targeted delivery of bioactive compounds. By favoring the follicle's adaptive response and modulating cellular communication pathways within the scalp microenvironment, this technology contributes to maintaining skin balance and long-term hair longevity.<\/p>

According to Mintel data:<\/p>

  • 59% of hair product users in Brazil consider it important to use specific scalp care products that nourish and promote healthy hair (Patent Insights: Tackle Hair-Loss and Thinning, Mintel, 2025).<\/li>
  • The \"skinification\" trend is intensifying in hair care, incorporating skincare ingredients\u2014such as exosomes\u2014into shampoos and conditioners. Their regenerative properties are associated with reduced hair loss and improved scalp health, reinforcing the connection between skin and hair (Patent Insights: Innovation in Shampoos & Conditioners, Mintel, 2025).<\/li>
  • Scalp care launches with anti-hair loss claims remain niche compared to other cosmetic promises, highlighting an untapped innovation opportunity (A Year of Innovation in Haircare, Styling & Colour, Mintel, 2025).<\/li>
  • Scalp health and hair loss are closely linked. Issues like residue buildup or skin imbalances contribute to hair thinning. Ignoring this association means missing a relevant and unmet consumer need (A Year of Innovation in Haircare, Styling & Colour, Mintel, 2025).<\/li>
  • In the last five years, global launches of hair products containing Curcuma longa (turmeric) have grown by more than 20% (GNPD, Mintel, 2025). Curcuma longa<\/em> (c\u00farcuma) han crecido m\u00e1s de un 20% (GNPD, Mintel, 2025).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t

    What is EXOREVAGE\u00a0<\/sup> Curcuma?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    The revolution in plant biotechnology to boost follicular activation.<\/strong><\/p>

    EXOREVAGE\u00a0<\/sup> Curcuma is a patent-pending technology developed by PREBEL, specifically designed for the formulation of non-invasive, needle-free hair and scalp care products.<\/p>

    This innovation incorporates plant exosomes from Curcuma longa<\/em>, modified with squalane\u2014a lipid permeation enhancer\u2014and ionic copper cofactors derived from malachite, a gemstone. The result is an intelligent delivery system with biomimetic membranes, offering high safety, efficacy, and controlled release of bioactive compounds.<\/p>

    This system promotes cellular regeneration, hair longevity, and hair follicle activation.<\/p>

    Both the Curcuma longa plant exosomes and the squalane are obtained through green biotechnology processes. Curcuma longa<\/em> como el escualano se obtienen mediante procesos de biotecnolog\u00eda verde.<\/p>

    EXOREVAGE\u00a0<\/sup> Curcuma is a versatile technology that can be formulated in combination with other actives and fragrances. It is suitable for both transparent and non-transparent products and can be incorporated into solutions, emulsions, cleansers, shampoos, and various cosmetic forms.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

    \n\t\t\t\t\t

    Key Ingredients of EXOREVAGE\u00a0<\/sup> Curcuma<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    The selection of ingredients follows strategic criteria of efficacy and functionality for the development of modified plant exosomes. This is not a simple mixture of components: in EXOREVAGE\u00ae\u00a0<\/sup> , they are structurally integrated to modify the exosome architecture and create functionalized Curcuma longa exosomes Curcuma longa<\/em>.<\/p>

    This cutting-edge technological integration optimizes their performance in advanced hair care applications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t

    \n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t

    Squalane<\/h3>\t\t\t\t<\/div>\n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    Squalane is a high-purity ingredient that biomimics the skin's natural lipids, making it a highly effective emollient.<\/p>

    It is obtained from sugar cane through fermentation processes based on green biotechnology, ensuring a sustainable origin and high functional quality for cosmetic applications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t

    Precious Malachite<\/h3>\t\t\t\t<\/div>\n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    Precious malachite is a liquid extract derived from this semi-precious stone, which is naturally rich in copper.<\/p>

    Copper plays an essential role in the scalp, notable for its antioxidant activity, detoxifying capacity, and contribution to processes associated with hair growth.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t

    Curcuma longa Plant Exosomes<\/h3>\t\t\t\t<\/div>\n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    Exosomes obtained from Curcuma longa<\/em> stem cells act as biological signaling vehicles, transporting peptides and bioactive factors\u2014including growth factors and epigenetic modulators\u2014capable of interacting with human follicles.<\/p>

    This cellular communication promotes the reactivation of the hair cycle and stimulates the processes associated with hair growth.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

    \n\t\t\t\t\t

    Functionalized exosome structure
    in EXOREVAGE\u00ae\u00a0<\/sup> Curcuma<\/h1>\t\t\t\t<\/div>\n\t\t
    \n\t\t
    \n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    The functionalized exosomes in EXOREVAGE\u00ae\u00a0<\/sup> Curcuma are developed from three main components, each with a specific technical role within the system:<\/p>

    Plant exosomes from Curcuma longa<\/em><\/strong>: <\/b>These act as biological vehicles for information and transport. They contain specialized bioactives and plant-derived peptides, performing key cellular signaling functions.<\/p>

    Copper ions (ionic cofactors)<\/strong>: <\/b>Derived from malachite. They modify the surface charge and form coordination complexes with receptors and cell membranes. This favors the interaction between the exosomes and skin cells, providing selective affinity and amplifying the system's efficacy.<\/p>

    Squalane (permeation enhancer)<\/strong>: <\/b>It integrates into the exosomal membranes, optimizing cellular fusion and promoting a more efficient release of the exosomal content.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
    \n\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t

    Comparison between conventional
    Curcuma longa exosomes and EXOREVAGE\u00ae Curcuma\u00a0<\/sup> Curcuma<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
    \n\t\t\t\t\t
    \n\t\t
    \n\t\t
    \n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
    \n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t

    Particle size distribution<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    Particle size distribution was evaluated in conventional Curcuma longa<\/em> exosomes and the functionalized exosomes present in EXOREVAGE\u00ae Curcuma.\u00a0<\/sup> .<\/p>

    Conventional Curcuma longa<\/em> exosomes are natural structures that have not undergone modification processes. These plant-derived exosomes present an average size near 273 nm and a polydisperse distribution.<\/p>

    After the functionalization process in EXOREVAGE\u00ae\u00a0<\/sup> Curcuma, the average particle size decreases to approximately 237 nm, representing a 13% reduction, along with a more homogeneous distribution.<\/p>

    These results suggest a structural reorganization and greater system stability, derived from the interaction between the exosomes and the functional components of the composition.<\/p>

    Furthermore, the particle concentration increases from $6.5 \\times 10^{10}$ particles\/mL in conventional Curcuma longa<\/em> to $6.83 \\times 10^{10}$ particles\/mL in EXOREVAGE\u00ae\u00a0<\/sup> Curcuma, indicating better dispersion and superior physical stability of the system.<\/p>

    Taken together, these findings demonstrate that EXOREVAGE\u00a0<\/sup> Curcuma presents a more uniform and stable structure compared to conventional Curcuma longa<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

    \n\t\t
    \n\t\t\t\t\t
    \n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
    \n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t

    Scanning Electron Microscopy (SEM)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    The structure of the plant-derived exosomes was analyzed using scanning electron microscopy (SEM).<\/p>

    Conventional plant exosomes from Curcuma longa<\/em> have an irregular and heterogeneous morphology, with poorly defined edges and greater variability in size.<\/p>

    In contrast, the functionalized plant exosomes in EXOREVAGE\u00a0<\/sup> Curcuma exhibit a well-defined spherical morphology, with sharp contours, greater uniformity in size, and a more compact surface texture. These characteristics demonstrate the formation of a stable coating and effective functionalization.<\/p>

    Overall, the results indicate that EXOREVAGE\u00a0<\/sup> Curcuma presents a more uniform and stable structure compared to conventional Curcuma longa<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

    \n\t\t
    \n\t\t
    \n\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t

    In Vitro Trials<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    Induction of Human Follicle Dermal Papilla Cell (HFDPC) proliferation<\/strong><\/p>

    EXOREVAGE\u00a0<\/sup> Curcuma was evaluated against the primary growth factors involved in the follicular growth cycle:<\/p>