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FUNCTIONALIZED EXOSOMES
FROM CURCUMA LONGA
The Trend
The growing scientific emphasis on scalp and hair longevity is shifting hair care beyond cosmetic conditioning toward preserving follicular function, scalp balance, and hair fiber quality over time. Traditional soothing and strengthening actives often have limited impact on the biological mechanisms of follicular aging, oxidative stress, and disrupted cellular communication, while chronic exposure to environmental stressors such as UV radiation, pollution, and mechanical damage accelerates scalp deterioration and loss of hair vitality.
Advances in plant-derived exosomes are designed to enhance intercellular signaling and targeted bioactive delivery. By promoting adaptive follicular response and modulating cellular signaling within the scalp microenvironment, this technology contributes to sustained scalp balance and long-term hair longevity.
Consumer trend data from Mintel shows:
- 59% of Brazilian haircare product users say it is important to use the right scalp care products to nourish the scalp and achieve healthy hair (Source: Patent insights: tackle hair-loss and thinning. Mintel, 2025)
- The ‘skinification’ trend intensifies in haircare revealing the inclusion of skincare ingredients like exosomes in shampoos and conditioners, in which their regenerative properties address hair-loss and improve scalp health, highlighting the connection between hair and skin (Source: Patent insights: innovation in shampoos & conditioners. Mintel, 2025)
- Scalp care launches carrying anti-hair loss claims remain niche, compared to those carrying other beauty-enhancing claims – signaling a missed opportunity (Source: A Year of Innovation in Haircare, Styling & Colour,2025. Mintel, 2025)
- Scalp health and hair-loss are closely linked, with issues like scalp build-up or imbalances contributing to thinning hair. By neglecting this association, brands are missing the chance to cater to a prevalent consumer concern and meet unmet consumer needs (Source: A Year of Innovation in Haircare, Styling & Colour, 2025. Mintel, 2025)
- During the last five years the hair care products launched to the market with Curcuma Longa (turmeric) have been increased by more than 20% globally (GNPD, Mintel, 2025)
What is EXOREVAGE® Curcuma?
THE PLANT BIOTECNOLOGY REVOLUTION TO BOOST FOLLICLE ACTIVATION.
EXOREVAGE® CURCUMA is a patent-pending technology developed by PREBEL. This technology was specially created to formulate needle-free and non- invasive scalp care and hair care products.
In EXOREVAGE® CURCUMA the plant exosomes from Curcuma longa are modified with squalane (lipidic permeation booster) and ionic cofactors of copper coming from precious malachite gemstone to create a smart delivery system with biomimetic membranes, high safety and efficacy and controlled release of bioactive compounds, boosting cell regeneration, hair longevity and follicle activation
The plant based exosomes from Curcuma longa and squalane are both obtained by green biotechnology.
This technology is versatile enough to be formulated with other active ingredients and fragrances. It can be used to formulate transparent and non-transparent products, solutions, emulsions, cleansers, shampoos, and the other cosmetic forms.
Hero Ingredients in EXOREVAGE® Curcuma
We have selected strategically both the most effective and functional ingredients to create modified plant-based exosomes. These components are not simply mixed together, this technology goes beyond. In EXOREVAGE® Curcuma, these components are integrated to modify the exosome structure and enable to form functionalized exosomes from Curcumla longa, as a cutting edge technology for hair care applications.
Squalane
Squalane is high purity ingrediente that mimics the skin´s natural oils, making it an excellent emollient.
It´s obtained from sugarcane using fermentation by green biotechnology.
Precious Malachite Gemstone
Precious malachite is a liquid extract from gemstone rich in cooper with essential functions as antioxidante, detoxifing, and hair growth.
Plant-Based Exosomes From Curcuma Longa
Exosomes from Curcuma Longa stem cells which transports signaling peptides, such as growth factor and epigenetic factors, which can communicate with human follicles and reactivate the hair cicle and hair growth.
Structure of Functionalized Exosomesin EXOREVAGE® Curcuma
The functionalized exosomes in EXOREVAGE® Curcuma are created by using three main components with very specialized roles:
PLANT-BASED EXOSOMES FROM CURCUMA: Carry information, specialized bioactives and plant-based peptides and it has cell signaling functions
COPPER IONS (IONIC COFACTORS): Coming from Malachite. Change the surface charge and form coordination complexes with receptors and membranes. Enhance the interaction between exosomes and skin cells, providing selective affinity and amplifying the efficacy
SQUALANE (PERMEATION BOOSTER): Integrates in the exosomes membranes and optimizes cell fusion and promotes more effective release of exosome content.
Comparison between
Conventional Exosomes from Curcumaand EXOREVAGE® Curcuma
Particle Size Distribution
Scanning Electron Microscopy (SEM)
The structure of the plant-based exosomes was analized by means of scanning electron microscopy (SEM).
Conventional plant-based exosomes from Curcuma longa show irregular and heterogeneous morphology, with poorly defined edges, greater size variability. In contrast, the functionalized plant-based exosomes in EXOREVAGE® CURCUMA exhibited a well-defined spherical morphology, with sharp contours, greater uniformity in size, and a more compact surface texture, characteristics that evidence the formation of a stable coating and effective functionalization.
These results indicate more stable and more uniform structure of EXOREVAGE® CURCUMA compared to conventional CURCUMA exosomes
In Vitro Tests
Induction of Human Follicle Dermal Papilla Cells (HFDPC) proliferation
EXOREVAGE® CURCUMA was evaluated against the main growth factors involved in the follicle growth cycle: FGF: Fibroblast Growth Factor, VEGF: Vascular Endothelial Growth Factor and IGF: Insulin Growth Factor – 1 in a test of Induction of Human Follicle Dermal Papilla Cells (HFDPC) proliferation. It’s found a 177% increase in proliferation with EXOREVAGE CURCUMA and a greater effect than other growth factors (FGF, VEGF, IGF-1).
Antioxidant Capacity
EXOREVAGE® CURCUMA was evaluated against conventional plant- based exosomes from curcuma longa in antioxidant capacity test using DPPH quantifying the mg Equivalent Trolox/ 100mL. It’s found up to 67% higher antioxidant capacity in EXOREVAGE CURCUMA compared to conventional CURCUMA exosomes.
In Vivo Tests
Evaluation On Scalp
In vivo tests conducted with 40 volunteers using a leave-on formula with EXOREVAGE® CURCUMA applied to the scalp daily up to 150 days.
- Restoration of the hair cycle by Trichogram: Up to 27% increase in the ratio Anagen/ Telogen (A/T) at 150 day of evaluation, showing an activation of the Anagen phase (hair growth) and reduction of the telogen phase (hair loss), demonstrating the effect of EXOREVAGE® CURCUMA in the restoration of the hair cycle
- Follicle activation by Trichoscan: Average increase in hair density of 15.3% and 17.3% at 90 and 150 days demonstrated by Micrography – Trichoscan evaluated directly in the scalp, demonstrating the effect of EXOREVAGE® CURCUMA in Follicle activation.
Evaluation On Eyelash & Eyebrows
In vivo tests conducted with 20 volunteers with serum with EXOREVAGE® CURCUMA applied to eyelashes and eyebrows daily up to 120 days.
Eyelash density by GEA
EXOREVAGE® CURCUMA increased eyelash density by up to 56% after 4 months of daily use.
Eyebrow density by GEBA
EXOREVAGE® CURCUMA increased eyebrow density by up to 35% after 4 months of daily.
Our product
