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THE PLANTBIOTECHNOLOGY
REVOLUTION
TO BOOST
FOLLICLE
ACTIVATION
What is EXOREVAGE® Curcuma?
EXOREVAGE® CURCUMA is a patent-pending technology developed by PREBEL. This technology was specially created to formulate needle-free and non- invasive scalp care products
In EXOREVAGE® CURCUMA the plant exosomes from Curcuma longa are modified with squalane (lipidic permeation booster) and ionic cofactors of copper coming from precious malachite gemstone to create a smart delivery system with biomimetic membranes, high safety and efficacy and controlled release of bioactive compounds, boosting cell regeneration, hair longevity and and follicle activation
The plant based exosomes from Curcuma longa and squalane are both obtained by green biotechnology.
This technology is versatile enough to be formulated with other active ingredients and fragrances. It can be used to formulate transparent and non-transparent products, solutions, emulsions, cleansers and the other cosmetic forms.
Hero Ingredients in EXOREVAGE® Curcuma
SQUALANE
Squalane is high purity ingrediente that mimics the skin´s natural oils, making it an excellent emollient.
It´s obtained from sugarcane using fermentation by green biotechnology.
PRECIOUS MALACHITE GEMSTONE
Precious malachite is a liquid extract from gemstone rich in cooper with essential functions as antioxidante, detoxifing, and hair growth.
PLANT-BASED EXOSOMES FROM CURCUMA LONGA
Exosomes from Curcuma Long stem cells which transports signaling peptides, such as growth factor and epigenetic factors, which can communicate with human follicles and reactivate the hair cicle and hair growth.
Structure of Functionalized Exosomesin EXOREVAGE® Curcuma
The functionalized exosomes in EXOREVAGE Curcuma have three main components with very specialized roles:
PLANT-BASED EXOSOMES FROM CURCUMA: Carry information, specialized bioactives and plant-based peptides and it has cell signaling functions
COPPER IONS (IONIC COFACTORS): Coming from Malachite. Change the surface charge and form coordination complexes with receptors and membranes. Enhance the interaction between exosomes and skin cells, providing selective affinity and amplifying the efficacy
SQUALANE (PERMEATION BOOSTER): Integrates in the exosomes membranes and optimizes cell fusion and promotes more effective release of exosome content.
Comparison between Plant-Based
Exosomes Curcuma
and EXOREVAGE® Curcuma
Particle Size distribution for conventional exosomes from Curcuma longa and functionalized exosomes in EXOREVAGE CURCUMA
Conventional exosomes from Curcuma longa are natural exosomes that have not being treated or modified. This conventional plant-based exosomes from Curcuma longa show an average size close to 273 nm and a polydisperse distribution. The functionalization of this exosomes in EXOREVAGE CURCUMA show that the average size of the exosomes decreases to approximately 237 nm, representing a reduction of 13%, along with a more homogeneous distribution. These changes suggest structural reorganization and greater stability derived from the interaction of exosomes with the functional components of the composition.
Likewise, the particle concentration increased from 6.5×10⁹ particles/mL in the conventional plant-based exosomes from Curcuma Longa to 6.83×10⁹ particles/mL in EXOREVAGE CURCUMA, indicating better dispersion and increased physical stability of the system.
These results indicate more uniform structure of EXOREVAGE CURCUMA compared to conventional CURCUMA exosomes
Comparison between Plant-Based
Exosomes Curcuma Longa
and EXOREVAGE® Curcuma
The structure of the plant-based exosomes was analized by means of scanning electron microscopy (SEM).
Conventional plant-based exosomes from Curcuma longa show irregular and heterogeneous morphology, with poorly defined edges, greater size variability. In contrast, the functionalized plant-based exosomes in EXOREVAGE® CURCUMA exhibited a well-defined spherical morphology, with sharp contours, greater uniformity in size, and a more compact surface texture, characteristics that evidence the formation of a stable coating and effective functionalization.
These results indicate more stable and more uniform structure of EXOREVAGE® CURCUMA compared to conventional CURCUMA exosomes
In Vitro Test
Induction of Human Follicle Dermal Papilla Cells (HFDPC) proliferation
EXOREVAGE® CURCUMA was evaluated against the main growth factors involved in the follicle growth cycle: FGF: Fibroblast Growth Factor, VEGF: Vascular Endothelial Growth Factor and IGF: Insulin Growth Factor – 1 in a test of Induction of Human Follicle Dermal Papilla Cells (HFDPC) proliferation. It’s found a 177% increase in proliferation with EXOREVAGE CURCUMA and a greater effect than other growth factors (FGF, VEGF, IGF-1).
Antioxidant Capacity
EXOREVAGE® CURCUMA was evaluated against conventional plant- based exosomes from curcuma longa in antioxidant capacity test using DPPH quantifying the mg Equivalent Trolox/ 100mL. It’s found up to 67% higher antioxidant capacity in EXOREVAGE CURCUMA compared to conventional CURCUMA exosomes.
EVALUATION ON SCALP
In vivo tests conducted with 40 volunteers using a leave-on formula with EXOREVAGE CURCUMA applied to the scalp daily up to 150 days.
- Restoration of the hair cycle by Trichogram
Up to 27% increase in the ratio Anagen/ Telogen (A/T) at 150 day of evaluation, showing an activation of the Anagen phase (hair growth) and reduction of the telogen phase (hair loss), demonstrating the effect of EXOREVAGE CURCUMA in the restoration of the hair cycle
- Follicle activation by Trichoscan
Average increase in hair density of 15.3% and 17.3% at 90 and 150 days demonstrated by Micrography – Trichoscan evaluated directly in the scalp, demonstrating the effect of EXOREVAGE CURCUMA in Follicle activation.
EVALUATION ON EYELASH & EYEBROWS
In vivo tests conducted with 20 volunteers with serum with EXOREVAGE CURCUMA applied to eyelashes and eyebrows daily up to 120 days.
Eyelash density by GEA
EXOREVAGE CURCUMA increased eyelash density by up to 56% after 4 months of daily use
Eyebrow density by GEBA
EXOREVAGE CURCUMA increased eyebrow density by up to 35% after 4 months of daily
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